Our laboratory produces a 4% Niacinamide (Vitamin B3) acne gel. In a State University of New York study, a 4% niacinamide gel was compared to a 1% clindamycin gel for the treatment of moderate inflammatory acne in 76 patients. Treatment was applied twice daily for eight weeks. At the end of treatment, 82 percent of the niacinamide patients and 68 percent of the clindamycin patients were improved. The fact that the use of topical clindamycin is also associated with the development of resistant microorganisms makes niacinamide even more preferred. Niacinamide gels have also been shown to reduce the amount of sebum present on the skin thus treating the cause of acne. We also add lipoic acid to improve the effectiveness of the gel as it too has been shown to help treat acne.